Substrate.

We study the structure of intelligence in machines, in molecules, and in the systems that shape our world.

Substrate is an independent research lab, working wherever the science is most promising.

Machines

Alignment

Training and oversight that keep models doing what we intend.

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Machines

Interpretability

Figuring out what's actually going on inside a model.

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Molecules

Biology

Using AI to read and design biological systems.

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Systems

Societal

How AI changes work, institutions, and power.

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Recent Work · 001

Papers and preprints.

What we've published so far, including work still in progress.

Origins · 002

Where the team comes from.

People here come from these labs and companies.

MIT
MIT Critical Data
MIT CSAIL
UC Berkeley
Stanford
Bluedot
Y Combinator